The organizing committee of the XVth International Workshop on Molecular and Cellular Biology of Plasminogen Activation invites scientists from around the world with interest in plasminogen activation and other proteolytic systems to join us from the 22nd – 26th of September 2015 at the University of Notre Dame Global Gateway Facility at Via Ostilia 15, Rome, Italy.  This newly renovated 32,000 square foot building is located within 2 blocks from the Colosseum.  It is home to the Notre Dame Rome programs in the School of Architecture and the College of Arts and Letters. This five-story stucco building features a courtyard, a kitchen, outdoor terraces, classrooms, office and meeting space, architecture and painting studios, and cutting-edge technology.

The plasminogen activation system and related proteolytic systems are essential regulators of tissue remodeling events as well as regulation of cell functions through activation of cell signaling pathways.  Through early studies involving in vitro biochemical investigations, and more recently in vivo biological studies involving gene modification technology, the plasminogen activation pathway has been identified as a major participant in the regulation and progression of a number of clinically relevant human diseases.  These include cancer, cardiovascular diseases, neurological pathologies, and bacterial pathogenesis.  Therefore, topics of relevance to this meeting include but are not limited to the following:

  • Structure/function of plasminogen activators, receptors, and inhibitors
  • Plasminogen activation system in neurobiology, neuropathology, and stroke
  • Plasmin and plasminogen activators at the matrix metalloproteinase (MMP) interface
  • Plasminogen activator system in angiogenesis and tumor biology
  • Novel membrane-associated serine proteases and kringle-containing proteins
  • Plasminogen activation system in tissue remodeling and repair, and cell senescence
  • Plasminogen activation system in inflammation, fibrosis, infection, and host defense
  • Plasminogen activation system in stem cell biology and hematopoiesis
  • Cell signaling mechanisms in the plasminogen activation system
  • Novel therapeutics targeting the plasminogen system
  • Plasminogen activation system in the acute coagulopathy of trauma

This meeting has been held in alternate years since 1985, and is unique in that it is almost exclusively abstract-driven.  Therefore, the majority of the presentations are selected from submitted abstracts.  This allows for the emphasis of the meeting to be on new and unpublished research, which fosters productive interchange of ideas between attendees of the meeting.  This year we will have a few State-of-the-Art presentations, which will highlight previous work in this area, as well as, project direction as to where this field is heading.  This is primarily for the benefit of new investigators in this area of research.  Posters will be displayed for the entire duration of the meeting to maximize opportunities for nurturing productive discussions and potential collaborations. The meeting space can only accommodate 110 people and, therefore, the meeting size will restricted.  So register SOON.  The organizing committee has arranged for accommodations in three different area hotels.  Since, September is considered high tourist season in Rome, please arrange for your accommodations to take advantage of the special rates and do this as soon as possible.

If you would like to be added to the e-mail list to receive announcements and additional information regarding the conference, please send your queries by e-mail to Geneva Miller at

Please check this web site periodically for additional information.  Registration and abstract submissions will begin early the first of the year.  Finally, there will be a number of fellowships for graduate students and postdoctoral fellows to offset a portion of the cost for attending this meeting.

We look forward to seeing you in Rome.

On behalf of the Organizing Committee,

Francis J. Castellino, Rashna D. Balsara, Victoria A. Ploplis, M. Patrizia Stoppelli, and Nicolai Sidenius